All posts by Pathology Horizons

A conference on what lies ahead for Pathology?

Dr. Louise Harewood to Speak on Cancer Genomics at Pathology Horizons 2019

Dr. Louise Harewood is the Scientific Lead for the Genomics division of the Precision Medicine Centre (PMC) in Belfast, Northern Ireland. The PMC is a new clinical laboratory that brings together high-throughput genomics, digital pathology and big data analytics in a fully integrated fashion. The aim of the centre is to accelerate the translation of potentially relevant diagnostic, prognostic and therapeutic findings into clinically actionable information by applying state-of-the-art technology in a clinical laboratory environment.

Louise has a strong genomics background, based largely around structural rearrangement and copy number variation detection, 3D nuclear organisation and genome regulation. Before joining the PMC, she held a position as an independent postdoc in the Innovation lab at the Cancer Research UK Cambridge Institute, a post created for her to enable continuation of a previous postdoc project and to bring in and develop new techniques within the building.

Talk Title: Cancer Genomics: A Precision Medicine Centre Perspective

Genomic abnormalities play a pivotal role in cancer diagnostics and prognostics, as well as helping to guide treatment choices for individual patients. Although genomic techniques to detect single gene mutations have long since been established in the clinical diagnostic workflow, many other actionable or diagnostic abnormalities, such as structural or copy number variants, continue to be detected by other methods (e.g. FISH, array based methods or cytogenetics) with many different tests often being required for a single patient.

Whilst genomic sequencing techniques, such as whole genome sequencing, can provide all of this information, they have historically been hindered by high costs, long turnaround times and a lack of suitable bioinformatic analysis tools. This, however, is rapidly changing:  – per base sequencing costs have dramatically reduced and sequencing has entered the realms of affordability for many clinical labs. Library preparation and sequencing protocols continue to be improved and made more amenable to automation. There are also a host of computational analysis tools now available on the market with others being continually developed.

The time is approaching when large-scale genomic analyses will be able to replace the multiple individual tests that are currently undertaken for clinical diagnostic purposes in many labs. The generated data will not only allow treatment to be more accurately tailored to individual patients, but also provide vital information about cancer subtypes, risk stratification and provide a vast collection of data that can be re-mined as new biomarkers are discovered.

In this talk, Dr. Harewood will discuss some of the approaches that they are investigating within the PMC with the aim of bringing new genomic technologies into the clinical diagnostic field.

Pathology Horizons 2019

Pathology Horizons is an annual and open CPD event organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these. Dr. Harewood will be joined by 13 more international industry experts with some of the topics including:

  • FHIR: transforming the pathology business relationship
  • Cancer Immunotherapy Biomarker
  • Digital Pathology
  • Light-sheet Microscopy
  • Machine Learning in Pathology
  • ctDNA testing for cancer

**Given the boutique nature of this conference places are limited, so please book early to guarantee your place.** Find out more about the speakers, agenda and registration here.

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Clinical metagenomics – are we there yet?

The use of metagenomic sequencing is becoming well-known in human microbiome testing. As high-throughput sequencing becomes more readily available and cost is lowering, more medical testing laboratories are considering the clinical use of shotgun metagenomics.

Clinical applications include identification of infectious agents directly from specimens, including when pathogens are not readily detected using conventional diagnostics. The diagnosis of systemic and central nervous system infections are examples of breakthroughs that have been described. In addition to pathogen identification and microbiome analysis, metagenomics can also be used to explore potential antimicrobial resistance. Clinical metagenomics can assist with therapeutic decision-making, as well as infection prevention and control. Understanding the benefits and barriers in the context of the clinical application is necessary to ensure safe clinical practice and determine regulatory compliance.  

In this presentation, Schlebusch will decode and explore the use of metagenomics in clinical practice.

 About  Dr. Schlebusch

 Dr. Schlebusch is an experienced clinical microbiologist recognised for her research, expertise and implementation of innovative technologies for diagnosis of infectious diseases and antimicrobial resistance. She has been the Director of Microbiology at Mater Pathology in Brisbane for the last 7 years. She has recently been appointed as Staff Specialist at Forensic and Scientific Services, Health Support Queensland. Forensic and Scientific Services is Queensland’s reference laboratory for notifiable conditions and routinely performs whole genome sequencing for disease surveillance, disease outbreaks and research.

Pathology Horizons | 8-10th August 2019

Dr. Schlebusch will present on Clinical Metagenomics at the Pathology Horizons conference  in Queenstown, New Zealand. 

The conference is an annual and open CPD event organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these. Dr. Schlebusch will be joined by 13 more international industry experts with some of the topics including:

  • FHIR: transforming the pathology business relationship
  • Cancer Immunotherapy Biomarker
  • Digital Pathology
  • Light-sheet Microscopy
  • Machine Learning in Pathology
  • ctDNA testing for cancer

Learn more and register.

**Given the boutique nature of this conference places are limited, so please book early to guarantee your place.**

Extreme Makeover: Creating Pathology Reports that Make a Difference

The centre of the pathology universe is the pathology report, but creating value from a Courier-font, paper-based document can be challenging. Pathologists now have the opportunity to integrate new technologies and design-minded thinking into what has previously been a static, unbending, and sometimes-misinterpreted showcase of their talent. Whole slide imaging, new static imagery, video, treatment algorithms, headlines, targeted summaries, and enhanced e-signatures can all provide opportunities to revive, enhance, and enrich pathology reports. This presentation will focus on creating value for patients by understanding disease processes, for clinicians by providing treatment road maps, and for pathologists by increasing marketability and practice enhancement. If you are in the business of generating diagnostic reports, this video of Dr. Glassy’s presentation from Pathology Horizons 2018 will help you make a difference.

Dr. Eric Glassy presenting at Pathology Horizons 2018 at the Lough Erne Resort in County Fermanagh, N. Ireland.

To view Dr. Glassy’s full video presentation please send your request to earmstrong@cirdan.com

About Eric Glassy

Dr. Glassy is a community pathologist in Southern California and director of pathology at Providence Little Company of Mary Medical Center, San Pedro. He is a member of Affiliated Pathologists Medical Group, a 40 person independent pathology group covering 18 hospitals and laboratories in California, Portland and Phoenix.

Dr. Glassy has served as medical director for several laboratories. He has won a number of pathology awards, including the Distinguished Service Award and Excellence in Education Award from the College of American Pathologists (CAP). He has chaired hospital and national committees for the CAP. He served as chairman of the Hematology and Clinical Microscopy Resource, Publications, and Curriculum Committees. He is past-chair of the Digital Pathology Committee and a past-Board Member of the CAP Foundation.  He is a graduate of the Engaged Leadership Academy. He is past-president of the Digital Pathology Association. He edited, wrote and illustrated several pathology color atlases and developed software programs for pathology reporting, outreach, and practice management. He holds a green belt in Six Sigma. He is a trustee of the American Board of Pathology as well as a board member of the College of American Pathologists.

What is Pathology Horizons?

Pathology Horizons is an annual and open CPD conference organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these. This unique event provides an opportunity to learn about new technologies, procedural developments and lines of research that are driving the future of pathology. It also provides the opportunity to contribute your ideas, interact with innovators from around the world, expand your knowledge and make some new contacts- all within a relaxed and beautiful setting!

Join us for Pathology Horizons 2019!

Registration for Pathology Horizons 2019 is officially open. With just 4 months to go and preparation well underway, we are getting very excited for what will be the 5th Pathology Horizons conference organised and hosted by Cirdan.

We promise an impressive programme covering a wide range of groundbreaking topics from a panel of international industry experts. Here’s a selection of just some of the topics you can expect to hear about:

  • Interoperability
  • Cancer Immunotherapy Biomarkers
  • Digital Pathology
  • Light-sheet Microscopy
  • Machine Learning in Pathology
  • ctDNA testing for cancer

**Given the boutique nature of this conference places are limited, so please book early to guarantee your place.**

“Nondestructive 3D pathology with open-top light-sheet microscopy for precision medicine”

The diagnostic gold standard of histology relies upon analog technologies that have changed little over the past century. These dated techniques contribute to large inter-pathologist variability, poor prognostication/prediction of tumor behavior in individual patients, and consequently, treatment that is often not optimized for an individual’s particular malignancy. 

We believe that in order to catalyze a digital pathology transformation, a technological approach is needed that offers significant advantages over traditional histopathology in terms of simplicity/cost, speed, accuracy, comprehensiveness of sampling, and superior sample preservation (including nucleic acids). 

Towards this end, we have developed an “open-top” light-sheet (OTLS) microscopy platform for rapid slide-free 3D pathology of surgical and biopsy specimens [Glaser et al, Nat. Biomed. Eng., 2017].  Our most-recent efforts have focused on optimizing a suite of technologies to demonstrate the feasibility of 3D OTLS microscopy to visualize structural and molecular biomarkers within large numbers of core-needle biopsies in toto, and ultimately to better predict patient outcomes (indolent vs. aggressive disease). 

These nondestructive and comprehensive digital pathology methods are synergistic with the rapidly growing fields of genomics and machine learning, which collectively have the potential to significantly improve patient prognostication and treatment stratification. 

Dr. Jonathan Liu will present his work mentioned above, at Pathology Horizons 2019 in Queenstown New Zealand on 8th- 10th August. Dr. Liu is the Bryan McMinn endowed associate professor of mechanical engineering at the University of Washington, with an adjunct appointment in the department of pathology.
His work has been funded by the NIH (NCI, NIDCR, NIBIB), NSF, Department of Defense and Fred Hutchinson Cancer Research Center. Dr. Liu’s molecular biophotonics laboratory develops optical strategies for improving the detection, diagnosis, and treatment of diseases. Read more..

Pathology Horizons

Pathology Horizons is an annual and open CPD conference organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these. This unique event provides an opportunity to learn about new technologies, procedural developments and lines of research that are driving the future of pathology. You will hear about the possible pros and cons of these developments, how people in supporting disciplines should be preparing for and perhaps directing these changes and their potential impact on the daily work of a pathologist. It also provides the opportunity to contribute your ideas, interact with innovators from around the world, expand your knowledge and make some new contacts- all within a relaxed and beautiful setting!C

EARLY BIRD REGISTRATION NOW OPEN

Registration for Pathology Horizons 2019 is officially open. With less than 5 months to go and preparation well underway, we are getting very excited for what will be the 5th Pathology Horizons conference organised and hosted by Cirdan.

We promise an impressive programme covering a wide range of groundbreaking topics from a panel of international industry experts. Here’s a selection of just some of the topics you can expect to hear about:

  • Interoperability
  • Cancer Immunotherapy Biomarkers
  • Digital Pathology
  • Light-sheet Microscopy
  • Machine Learning in Pathology
  • ctDNA testing for cancer

**Given the boutique nature of this conference places are limited, so please book early to guarantee your place.**

Prof. Stephen Fox to speak at Pathology Horizons 2019

We are delighted to welcome Professor Stephen Fox on to the panel of speakers for Pathology Horizons 2019. Stephen is the Director of Pathology at the Peter MacCallum Cancer Centre in Australia and Professorial Fellow at the University of Melbourne.

He holds Honours degree and Medical degrees from the University of Bristol, UK and a DPhil in Medicine from the University of Oxford. He has Fellowships of both the Royal College of Pathologists Australasia (RCPA) and UK and is also a Founding Fellow of the Faculty of Science (RCPA). He is an NHMRC Practioner Fellow and a Fellow of the Australian Academy of Health and Medical Sciences. His current focus is development of diagnostic predictive markers of response to therapies in several tumour types using protein and DNA-based assays.

Prof. Stephen Fox will present on ctDNA testing for cancer at Pathology Horizons 2019. Further information on this talk will be announced in the coming weeks.

Pathology Horizons 2019

Pathology Horizons is an annual and open CPD conference organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these. This year the conference will take place in the exquisite Heritage Hotel Queenstown, New Zealand. The vistas from Heritage Queenstown are awe-inspiring – soak in the view of the towering Remarkables mountain range, rising from the rippling waters of Lake Wakatipu from the comfort of the hotel. Crafted from centuries-old schist stone and cedar, this comfortable and sophisticated Queenstown hotel is the perfect place to mix business and pleasure.

Heritage Hotel Queenstown, New Zealand.

Early Bird Registration

Early Bird registration opens next week, however you can register here to receive advanced notification and purchase tickets two days before registration officially opens.

Be part of the discussion on the future of pathology! 

Grahame Grieve to talk Interoperability at Pathology Horizons 2019

We are delighted to announce that Grahame Grieve from Health Intersections Pty Ltd, Australia will speak on the topic of interoperability at Pathology Horizons 2019.

Grahame Grieve is HL7’s Product Director for “FHIR” – the leading healthcare data exchange standard of the future. Grahame has a background in laboratory medicine, software vendor development, clinical research, open source development and has also conceived, developed and sold interoperability and clinical document solutions and products in the Australian market and around the world. Grahame has worked to develop standards and solutions with several US vendor consortiums, and the national programs of Canada, England, Singapore, Vietnam, and Australia.

Pathology Horizons 2019

Pathology Horizons is an annual and open CPD conference organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these.

This year the conference will take place in the exquisite Heritage Hotel Queenstown, New Zealand. The vistas from Heritage Queenstown are awe-inspiring – soak in the view of the towering Remarkables mountain range, rising from the rippling waters of Lake Wakatipu from the comfort of the hotel. Crafted from centuries-old schist stone and cedar, this comfortable and sophisticated Queenstown hotel is the perfect place to mix business and pleasure.

If you would like to be notified when Pathology Horizons 2019 registration opens, please click here.

Opportunities outweigh the challenges of radiology and pathology integration

At Pathology Horizons 2018 , Dr. Dean Wallace of UCLA David Geffen School of Medicine in Los Angeles, California provided an interesting overview of radiology and pathology integration that is currently live in his practice. During the presentation, Dr. Wallace guides us through his experiences and developments in pathology and radiology integration and how it has been valuable to him as a pathologist.

View video of full presentation below

About Dr. Dean Wallace

Dr. W. Dean Wallace is a Professor of Pathology at the UCLA David Geffen School of Medicine in Los Angeles, California.  Dr. Wallace is the chief of pulmonary and renal pathology services and is recognized as an expert in the fields of transplant pathology and lung cancer diagnostics.

Dr. Wallace is also the Director of the UCLA Telepathology and Digital Pathology Center and co-led the team that created the innovative, first of its kind, Integrated Diagnostic Report (IDR) that combines multiple radiology and pathology studies into one dynamic reporting platform.  Dr. Wallace has authored several dozen peer-reviewed papers and book chapters and was lead editor of a textbook in the field of transplant pathology.

Pathology Horizons 2019

Pathology Horizons is an annual and open CPD conference organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these.

This year the conference will take place in the exquisite Heritage Hotel Queenstown, New Zealand. Queenstown. The vistas from Heritage Queenstown are awe-inspiring – soak in the view of the towering Remarkables mountain range, rising from the rippling waters of Lake Wakatipu from the comfort of the hotel. Crafted from centuries-old schist stone and cedar, this comfortable and sophisticated Queenstown hotel is the perfect place to mix business and pleasure.

If you would like to be notified when Pathology Horizons 2019 registration opens, please click here.

Application of liquid biopsy to the detection and treatment of ovarian cancer

Dr. Niamh Buckley of Queen’s University Belfast delivered an insightful presentation into the ongoing research conducted by the Professor and her team at QUB. The presentation which took place at the Pathology Horizons conference on Friday 14th September in N. Ireland, highlights how liquid biopsies are an emerging tool to allow the study of biomarkers in bodily fluids, including blood, urine and saliva. This limitless resource allows key biological information to be obtained about the specific disease in a minimally invasive manner.  In the context of cancer, liquid biopsies can be used to screen and/or diagnose patients with cancer as well as to stratify patients based on prognosis or predicted drug response.  Together this allows for a personalised medicine approach to be used to tailor management and/or treatment options based on specific knowledge of the underlying biology of the disease.

The presentation briefly touches on what liquid biopsies are, an introduction to ovarian cancer, as well as the strategy they have employed at Queen’s University to address and try to identify some novel liquid biopsy options. It concludes with where they are in trying to make this research a reality.

To view the full presentation, email a request to marketing@cirdan.com

Pathology Horizons 2019

Pathology Horizons is an annual and open CPD conference organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these.

This year the conference will take place in
the exquisite Heritage Hotel Queenstown, New Zealand. Queenstown  is one of the great alpine regions of the world and the charming Heritage Queenstown Hotel calls this place home – the resort offers a hotel experience certain to leave you breathless. The vistas from Heritage Queenstown are awe-inspiring – soak in the view of the towering Remarkables mountain range, rising from the rippling waters of Lake Wakatipu from the comfort of the hotel. Crafted from centuries-old schist stone and cedar, this comfortable and sophisticated Queenstown hotel is the perfect place to mix business and pleasure.

Learn more about Pathology Horizons.

Opportunities outweigh the challenges of radiology and pathology integration

Dr. W. Dean Wallace is a Professor of Pathology at the UCLA David Geffen School of Medicine in Los Angeles, California.  Dr. Wallace is the Chief of Pulmonary and Renal Pathology Services and is recognized as an expert in the fields of transplant pathology and lung cancer diagnostics.

Dr. Wallace is also the Director of the UCLA Telepathology and Digital Pathology Center and co-led the team that created the innovative, first of its kind, Integrated Diagnostic Report (IDR) that combines multiple radiology and pathology studies into one dynamic reporting platform.  Dr. Wallace has authored several dozen peer-reviewed papers and book chapters and was lead editor of a textbook in the field of transplant pathology.


Short interview with Dr. Dean Wallace, UCLA, USA at the Pathology Horizons 2018 conference. Dr. Wallace discusses his views on what the future holds for radiology and pathology integration along with the challenges that lie ahead in this area.

If you would like to like to watch Dean Wallace’s full talk from Pathology Horizons 2018- please email earmstrong@cirdan.com.

Interested in attending next year’s conference? Find out more and pre-register here.

Hear from Prof. Armes on the future of genome sequencing

Prof. Jane Armes, NSW Health Pathology, Australia spoke on “Genome Sequencing as a Diagnostic Aid” at the recent Pathology Horizons 2018 conference in N.Ireland.

In the short interview below filmed  after her presentation, Prof. Armes talks a little bit about her background, where she believes the future of genome sequencing lies, the challenges ahead and gives her thoughts on the Pathology Horizons conference.

About Pathology Horizons

Pathology Horizons is an annual CPD conference, which draws an international audience and is focused on the future of pathology. Delegates learn about new technologies, lines of research and procedural developments that are driving the future of pathology.

Unlike other larger pathology conferences, Pathology Horizons has just one conference stream allowing attendees to network more easily with both speakers and delegates.

Pathology Horizons 2019

The 2019 conference takes place in The Heritage, Queenstown, New Zealand from 8-10 August. Due to the boutique nature of this conference, places are limited. To keep informed of the agenda and when early bird registration opens, pre-register here.