Tag Archives: Artificial intelligence

Artificial Intelligence and Computational Pathology: Implications for Precision Medicine

With the advent of digital pathology, there is an opportunity to develop computerized image analysis methods to not just detect and diagnose disease from histopathology tissue sections, but to also attempt to predict risk of recurrence, predict disease aggressiveness and long term survival. At the Center for Computational Imaging and Personalized Diagnostics, our team has been developing a suite of image processing and computer vision tools, specifically designed to predict disease progression and response to therapy via the extraction and analysis of image-based “histological biomarkers” derived from digitized tissue biopsy specimens. These tools would serve as an attractive alternative to molecular based assays, which attempt to perform the same predictions.

The fundamental hypotheses underlying our work are that: 1) the genomic expressions detected by molecular assays manifest as unique phenotypic alterations (i.e. histological biomarkers) visible in the tissue; 2) these histological biomarkers contain information necessary to predict disease progression and response to therapy; and 3) sophisticated computer vision algorithms are integral to the successful identification and extraction of these biomarkers. We have developed and applied these prognostic tools in the context of several different disease domains including ER+ breast cancer, prostate cancer, Her2+ breast cancer, ovarian cancer, and more recently medulloblastomas. For the purposes of this talk Dr. Madabhushi will focus on their work in breast, prostate, rectal, oropharyngeal, and lung cancer.

About Dr. Anant Madabhushi

Dr. Madabhushi is the Director of the Center for Computational Imaging and Personalized Diagnostics (CCIPD). He is also the F. Alex Nason Professor II in the Departments of Biomedical Engineering, Pathology, Radiology, Radiation Oncology, Urology, General Medical Sciences, and Electrical Engineering and Computer Science at Case Western Reserve University.

Madabhushi received his Bachelors Degree in Biomedical Engineering from Mumbai University, India in 1998 and his Masters in Biomedical Engineering from the University of Texas, Austin in 2000. In 2004 he obtained his PhD in Bioengineering from the University of Pennsylvania and joined the Department of Biomedical Engineering, Rutgers University as an Assistant Professor in 2005. He was promoted to Associate Professor with Tenure in 2010. In 2012 he accepted the position of Associate Professor at Case Western Reserve University, Department of Biomedical Engineering and is currently directing a center on computational imaging and personalized diagnostics. He was promoted to full professor in 2014.

Dr. Madabhushi has authored over 150 peer-reviewed journal publications  and over 180 conferences papers and delivered over 240 invited talks and lectures both in the US and abroad. He has over 75 patents either issued or pending in the areas of medical image analysis, computer-aided diagnosis, and computer vision.  He has been the recipient of a number of awards for both research as well as teaching, including the Department of Defense New Investigator Award in Lung Cancer (2014), the Coulter Phase 1 and Phase 2 Early Career award (2006, 2008), and the Excellence in Teaching Award (2007-2009), along with a number of technology commercialization awards.  His research work has received grant funding from the National Cancer Institute (NIH), National Science Foundation, the Department of Defense, private foundations, and from Industry. 

Pathology Horizons 2019

Pathology Horizons is an annual and open CPD event organised by Cirdan to discuss what developments lie ahead in Pathology and what we can do to prepare or take advantage of these. Dr. Harewood will be joined by 13 more international industry experts with some of the topics including:

  • FHIR: transforming the pathology business relationship
  • Cancer Immunotherapy Biomarker
  • Digital Pathology
  • Light-sheet Microscopy
  • Machine Learning in Pathology
  • ctDNA testing for cancer

**Given the boutique nature of this conference places are limited, so please book early to guarantee your place.** Find out more about the speakers, agenda and registration here.

Application and Implementation of AI Driven Screening Processes in Pathology

Dr. Donal O’Shea, Deciphex

Developing deep learning models that account for all variants of abnormality in a given tissue slide can be a challenge requiring extensive and time consuming annotation of thousands of pathology slides by experienced pathologists. The process also needs to effectively account for tissue processing variance and digital pathology scanner selection, which is almost infinite due to the extensive range of interchangeable unit operations available for the pathology lab.

In scenarios where a high percentage of normal content presents, we propose a generalised model for abnormality detection to help identify abnormal content of interest and support the elimination of normal cases from the workflow.  The generalised model as proposed is developed solely from normal cases, requires no annotation of slides as a result and can be rapidly tailored to account for inter-laboratory processing variance.

During his presentation,“Finding Normals: Application and Implementation AI Driven Screen Processes in Pathology”Dr. O’Shea will discuss how such approaches can be leveraged, useful application segments for the technology and how he foresees this capability being embodied in software workflows.

View more on Dr. Donal O’Shea

About Pathology Horizons

Pathology Horizons is taking place from 13-15 September 2018 at the Lough Erne Resort in N.Ireland. It is a unique CPD conference, organised by Cirdan that looks at what lies ahead in pathology. Delegates will learn about new technologies, lines of research and procedural developments that are driving the future of pathology. View Agenda

Please note that given the nature of this boutique style conference that there are only a limited number of places available. If planning on attending booking soon is advisable. Register here

Pathology Horizons – It’s almost time!

With just over two months to go until the next Pathology Horizons conference excitement is starting to build. Here’s some insight into why there is such a buzz around this event.

What’s it all about?

Pathology Horizons is an annual CPD conference organised by Cirdan, which focuses on what lies ahead in pathology. Delegates attending this unique event, now in its fourth year will learn about new technologies, lines of research and procedural developments that are driving the future of pathology.

Unlike other larger pathology events, Pathology Horizons is a boutique conference with only one conference stream, allowing delegates and speakers to interact easily with each other, providing an excellent networking and learning environment.

International Experts and Groundbreaking Topics

A first class panel of speakers from across the globe, including some of the best minds in the areas of pathology, laboratory medicine and personal and organisational development have been lined up to deliver presentations. Some talks to look forward to include:

  • Virtual and Augmented Reality in Digital Pathology
  • Application of Liquid Biopsy to the Detection and Treatment of Ovarian Cancer
  • Genome Sequencing as a Diagnostic Aid
  • Emerging Neuropathology Diagnostics: Genetic Scaffolds, Phenotypes and Advanced Imaging
  • Advancing Diagnostic Pathology: Impact of Digital Pathology and Artificial Intelligence Tools
  • Extreme Makeover: Creating Pathology Reports that Make a Difference

View full agenda

Who’s attending?

The conference is open to anyone interested in the area of pathology and laboratory medicine, for example Pathologists, Biomedical Scientists and other Laboratory Professionals. Confirmed delegates this year are coming from as far afield as New Zealand and work in a mix of clinical, academic and industry settings.

What’s in it for me?

As well as the obvious learning and networking opportunities delegates can earn CPD credits for attending. The conference has been CPD certified and is approved by the Royal College of Pathologists for nine CPD credits. The added bonus is that you can get all of this professional development in a relaxed and fun environment within a five star luxury resort.

Where is Pathology Horizons being held?

The conference is being held in the Lough Erne Resort, one of Northern Ireland’s finest hotels, just outside Enniskillen in Co. Fermanagh.

What can I expect?

Here’s a quick overview of last year’s conference in Cairns, Australia. Please note having a world-class golf course onsite is not a mandatory requirement when selecting a Pathology Horizons venue 🙂

Hear from some past delegates and speakers

How can I join the conference?

For details on how to register go to www.pathologyhorizons.com/register There is always a lot of interest in this unique event and demand has been greater than ever before this year. If you are interested in attending please book soon as there are a limited amount of places remaining.

Dr. Kaplan talks Artificial Intelliegnce: What it Means for Healthcare and Pathology

Recent advances in Artificial Intelligence (AI) show great promise in several fields of medicine.  The field of deep learning is enabling the development of expert-level automated algorithms.

There are two aspects to consider when looking at the value in  using AI. First is the practical aspect. Use of AI can speed up the diagnostic process, ensuring diagnostic assessments are more reproducible. This helps physician productivity by automating some of the decision-making process.

The deeper aspect of AI’s impact is in its ability to analyze the data found. AI algorithms will begin to find patterns a human wouldn’t necessarily see, extending the capability of what physicians can do today. These advances could address the impact treatment of the disease has on outcomes.

AI is simply a tool – not a replacement for a pathologist. Deep learning can be applied to numerous diagnostic tasks and defines a new era in digital pathology.

Dr. Keith Kaplan, Chicago native and Publisher of leading industry blog tissuepathology.com will be discussing artificial intelligence, what it means for healthcare and pathology at the Pathology Horizons Conference this September in N.Ireland.

During his session  Dr. Kaplan will focus on advancements in AI in surgical pathology and what the use of this technology means for the future practice of pathology.

Objectives for this session:

  • Understand basic definitions in AI and deep learning.
  • Review applications and use cases to date within medicine and pathology
  • Discuss implications of AI for the practice of pathology
  • Highlight potential opportunities and weaknesses for AI within pathology

View Conference Agenda

Register now for Early Bird!

Dr. Kaplan to speak on Artificial Intelligence at Pathology Horizons 2018

Cirdan is pleased to announce that Dr. Keith Kaplan, publisher of the industry’s leading pathology blog, tissuepathology.com will be joining the Pathology Horizons 2018 speaker panel. Dr. Kaplan’s presentation will be on: “Artificial Intelligence: What it means for Healthcare and Pathology.”

 

About Dr. Kaplan

Dr. Kaplan is a native of Chicago and a graduate of Michigan State University and Northwestern University Feinberg School of Medicine. He completed residency training in anatomic and clinical pathology at Walter Reed Army Medical Center, Washington, DC. While at Walter Reed, Dr. Kaplan was named Resident of the Year, and in conjunction with the Armed Forces Institute of Pathology, Dr. Kaplan founded and directed the Army Telepathology Program. This Program connected 25 hospitals internationally for consultation via telepathology. Dr. Kaplan was also with Mayo Clinic, Rochester, Minnesota as an Associate Professor of Pathology of Mayo Medical School. Read more on Dr. Kaplan

About Pathology Horizons

Pathology Horizons is an annual CPD conference focused on the future of pathology. Delegates will learn about new technologies, procedures and lines of research that are driving the future of pathology. This year the conference is being held in the five star Lough Erne Resort, Co. Fermanagh in N.Ireland from 13-15 September 2018.

View conference speakers and find out more  on how to register.

Early Bird Tickets now available.

Computer Aided Diagnosis in Pathology: Pros and Cons

 

Computer-Aided-Diagnosis-in-Pathology-2Artificial Intelligence (AI) is becoming a reality in medicine. However, can these deep learning tools perform the complex tasks of Pathologists, and in some instances with superior accuracy? Image analysis is one of the main reasons pathology labs are thinking about investing in digital pathology, especially since precision medicine currently demands precision diagnostics.

Enough evidence has been accrued showing that image analysis offers better accuracy, standardization, automation, and enables computational pathology. However, there are still several drawbacks and barriers preventing widespread adoption such as limited interoperability, workflow disruption, poor reimbursement, no guidelines, and regulatory obstacles.

Dr. Liron Pantanowitz,University of Pittsburgh, USA  discussed the benefits and problems relating to computer aided diagnosis in pathology and emphasized what is required to develop those awaited killer apps during his talk at the Pathology Horizons 2017 Conference in Cairns.

View Dr. Pantanowitz’s presentation below.